The results were mostly similar for all other outcomes without increasing the risk of adverse effects. Compared to bDMARD monotherapy, combination therapy gives a better ACR 20 at 24 weeks (RR: 0.88 (0.84-0.94)) in fixed and random effect models, and this result is sustained at 52 and 104 weeks. No study satisfied our search criteria for anakinra, certolizumab and infliximab. Major outcome: ACR 20 response criteria at 24 weeks.Ĭlinical and radiographic criteria at week 24, 52 and 104.Ģ3 trials (6358 patients), including seven bDMARDs and one other molecule: Anbainuo (anti-TNF-R). Research was limited to randomized controlled trials. Update the available evidence comparing biologic disease-modifying antirheumatic drugs (bDMARDs) in combination with conventional synthetic disease-modifying antirheumatic drugs (CsDMARDs) to bDMARDs in monotherapy in patients with rheumatoid arthritis. Limitations and directions for future research are explored. ![]() Additionally, both programs allow for reliable extraction of data between raters and between software programs. Study findings suggest that both GraphClick and DataThief III provide valid methods of data extraction. The purpose of this study was to evaluate and compare the validity and reliability of the results yielded by each of these programs when evaluating the results of multiple research studies on the Good Behavior Game, a classroom-based intervention which has been in practice since 1969. ![]() Researchers consistently use two software programs, DataThief III and GraphClick to conduct meta-analytic work using SSEDs. Until recently, researchers wishing to undertake meta-analytic research themselves have had limited options for synthesizing the intervention effects of a collection of studies. ![]() In the realm of single-subject experimental designs (SSEDs), meta-analyses have a particular cachet: retaining the rigor of single-subject designs with the added robustness of replication to more fully determine the strength of a given approach or intervention. Researchers frequently rely on meta-analyses of prior research studies to efficiently evaluate a broad spectrum of results on a particular topic.
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